Medizinische Universitätsklinik Bochum

www.medunikkh.de

Frau PD Dr. rer. nat. Schwarte-Waldhoff

Publikationen

Diehl, H.C., Stühler, K., Klein-Scory, S., Volmer, M.W., Schöneck, A., Bieling, C., Schmiegel, W., Meyer, H.E., Schwarte-Waldhoff, I.
A catalogue of proteins released by colorectal cancer cells in vitro as an alternative source for biomarker discovery.
Proteomics Clinical Applications 2007, 1, 47-61

Stuhler, K., Koper, K., Pfeiffer, K., Tagariello, A., Souquet, M., Schwarte-Waldhoff, I., Hahn, S. A., Schmiegel, W., and Meyer, H. E.
Differential proteome analysis of colon carcinoma cell line SW480 after reconstitution of the tumour suppressor Smad4. Anal Bioanal Chem, 386: 1603-1612, 2006.

Marc Zapatka, Dirk Zboralski, Yvonne Radacz, Miriam Böckmann, Christine Arnold, Anna Schöneck, Sabine Hoppe, Andrea Tannapfel, Wolff Schmiegel, Patricia Simon-Assmann and Irmgard Schwarte-Waldhoff
Basement membrane component laminin-5 is a target of the tumor suppressor Smad4.
Oncogene, advance online publication 4 September 2006; doi: 10.1038/sj.onc.1209918.

Volmer, M.W., Stühler, K., Zapatka, M., Schöneck, A., Klein-Scory, S., Schmiegel, W., Meyer, H.E., Schwarte-Waldhoff, I. Differential proteome analysis of conditioned media to detect Smad4 regulated secreted biomarkers in colon cancer. Proteomics 2005 Jul;5(10):2587-601

Baldus, S.E., Schwarz, E., Lohrey, C., Zapatka, M., Landsberg, S., Hahn, S.A., Schmidt, D., Dienes, H.P., Schmiegel, W., Schwarte-Waldhoff, I. Smad4 deficiency in cervical carcinoma cells. Oncogene, 2005 Jan 27;24(5):810-9.

Volmer M.W., Radacz, Y., Hahn, S.A., Klein-Scory, S., Stühler, K., Zapatka, M., Schmiegel, W., Meyer, H.E., and Schwarte-Waldhoff, I. Tumor suppressor Smad4 mediates down-regulation of the anti-adhesive invasion-promoting matricellular protein SPARC: Landscaping activity of Smad4 as revealed by a “secretome” analysis. Proteomics, 4: 1324-1334, 2004.

Reinacher-Schick, A., Baldus, S.E., Romdhana, B., Landsberg, S., Zapatka, M., Mönig, S.P., Hölscher, A.H., Dienes, H.P., Schmiegel, W., and Schwarte-Waldhoff, I., Loss of Smad4 correlates with loss of the invasion suppressor E-cadherin in advanced colorectal carcinomas.
J. Pathol., 2004;202(4):412-20.

Schwarte-Waldhoff, I., Funktionen des Tumorsuppressorgens Smad4 in der mehrstufigen Karzinogenese. BIOspektum, 3/03.

Reinacher-Schick, A., Schoeneck, A., Graeven, U., Schwarte-Waldhoff, I., and Schmiegel, W., Mesalazine causes a mitotic arrest and induces caspase dependent apoptosis in colon carcinoma cells. Carcinogenesis. 2003 Mar;24(3):443-51.

Schwarte-Waldhoff, I., and Schmiegel, W., Smad4 transcriptional pathways and angiogenesis. Int. J. Gastroint. Cancer. 2002. 31: 47-59.

Müller, N., Reinacher-Schick, A., Baldus, S., van Hengel, J., Berx, G., van Roy, F., Schmiegel, W., and Schwarte-Waldhoff, I., Smad4 induces the tumor suppressor E-cadherin and P-cadherin in colon carcinoma cells, Oncogene. 2002 Sep 5;21(39):6049-58.

Lüttges, J., Galehdari, H., Bröcker, V., Schwarte-Waldhoff, I., Henne-Bruns, D., Klöppel, G., Schmiegel, W., and Hahn, S. A. Allelic loss is often the first hit in the biallelic inactivation of the p53 and DPC4 genes during pancreatic carcinogenesis, Am. J. Pathol., 2001. 158: 1677-1683.

Schwarte-Waldhoff, I., Volpert, O.V., Bouck, N.P., Sipos, B., Hahn, S.A., Klein-Scory, S., Lüttges, J., Klöppel, G., Graeven, U., Eilert-Micus, C., Hintelmann, A., Schmiegel, W., Smad4/DPC4-mediated tumor suppression through suppression of angiogenesis. Proc Natl Acad Sci U S A. 2000 97(17):9624-9.

Schwarte-Waldhoff, I., Klein, S., Blass-Kampmann, S., Hintelmann, A., Eilert, C., Dreschers, S., Kalthoff, H., Hahn, S.A., Schmiegel, W., DPC4/SMAD4 mediated tumor suppression of colon carcinoma cells is associated with reduced urokinase expression. Oncogene. 1999 May 20;18(20):3152-8

Klein-Scory S, Zapatka M, Eilert-Micus C, Hoppe S, Schwarz E, Schmiegel W, Hahn SA, Schwarte-Waldhoff I. High-level inducible Smad4-reexpression in the cervical cancer cell line C4-II is associated with a gene expression profile that predicts a preferential role of Smad4 in extracellular matrix composition. BMC Cancer 2007;7:209.

Zboralski D, Bockmann M, Zapatka M, Hoppe S, Schoneck A, Hahn SA, Schmiegel W, Schwarte-Waldhoff I. Divergent mechanisms underlie Smad4-mediated positive regulation of the three genes encoding the basement membrane component laminin-332 (laminin-5). BMC Cancer 2008;8:215.